Preliminary analysis of the sinusoidal endothelium and space of Disse in ageing Papio hamadrayas

نویسندگان

  • Victoria C Cogger
  • Alessandra Warren
  • Robin Fraser
  • Meng Ngu
  • Allan J McLean
  • David G Le Couteur
چکیده

Address: 1Centre for Education and Research on Ageing and ANZAC Research Institute, University of Sydney, Concord RG Hospital, Sydney, Australia, 2Department of Pathology, Christchurch School of Medicine and Health Sciences, University of Otago, Christchurch, New Zealand, 3Department of Gastroenterology, Concord RG Hospital, Sydney, Australia and 4National Ageing Research Institute, Parkville, Melbourne, Australia

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Endothelial Vasodilator Angiotensin Receptors are Changing in Mice with Ageing

Background: The vascular function of Angiotensin II-type-2 receptors in adults is controversial. We sought their location and function in mouse aortic rings at young and old mice. Materials and Methods: Male C57Bl mice (aged 4 and 14 months) were killed by CO2. The descending thoracic aorta was cleaned and dissected into rings. Aortic rings were mounted in Krebs’ solution at 37 °C an...

متن کامل

The hepatic pharmacokinetics of doxorubicin and liposomal doxorubicin.

To determine the role of the hepatic sinusoidal endothelium in the hepatic disposition of liposomal doxorubicin, we compared the hepatic pharmacokinetics of doxorubicin hydrochloride and the pegylated, liposomal formulation of doxorubicin (Caelyx). The multiple indicator-dilution technique and electron microscopy were used to study the disposition of doxorubicin and liposomal doxorubicin in the...

متن کامل

Effects of acetaminophen on hepatic microcirculation in mice

Introduction Acetaminophen (APAP) intoxication from overdosing can result in severe hepatic damage, which is characterized by hemorrhagic centrilobular necrosis and by towering the levels of transaminase. The APAP-induced hepatic necrosis is preceded by centrilobular microvascular congestion thought to be due to collapse of the sinusoidal wall and the infiltration of blood elements into the spa...

متن کامل

Inhibition of matrix metalloproteinases minimizes hepatic microvascular injury in response to acetaminophen in mice.

The acetaminophen (APAP)-induced hepatic centrilobular necrosis is preceded by hepatic microcirculatory dysfunction including the infiltration of erythrocytes into the space of Disse. The purpose of this study was to examine the involvement of matrix metalloproteinases (MMPs) in the hepatic microvascular injury elicied by APAP. Male C57Bl/6 mice were pretreated with 2-[(4-biphenylsulfonyl) amin...

متن کامل

Handout - Clinical science for physicists and engineers course Page 1 of 4 Liver function and failure

1. Normal liver anatomy and function The normal liver is constituted by 2 lobes, with a weight of approximately 1400-2100 g and holds approximately 13% of the body's blood supply, with a dual blood perfusion via the hepatic artery (25%) and portal vein (75%). The liver parenchyma is organized into small units (acini) that are characterized by an incoming blood supply from portal tracts (branche...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Comparative Hepatology

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2004